The day before, Chinese Academy of Sciences Shanghai Life Science Research Institute researcher Wang Hui research group found that titanium dioxide nanoparticles in a TLR4 dependent manner to change the activity of macrophages, thus breaking the immune balance. Related papers were published online in the international academic journal Nanotoxicology.
In the food industry, titanium dioxide is widely used as food additives, food packaging materials or dietary supplements. Although the present study suggests that TiO2 food grade not what harm to the human body; but it is worth noting that chewing gum and candy, cakes and other foods, about 10% - 36% of the titanium dioxide particles in nanometer scale. The same substance changes from normal size to nanometer state, and its physical and chemical properties change. This makes nano science has become a hot spot in early twenty-first Century, but it is precisely because of this characteristic, the toxicity characteristic of nano materials and corresponding micron materials were different, the potential security raised concerns. Therefore, it is important to evaluate the health effects of dietary intake of TiO2 nanoparticles.
Wang Hui task force simulated food sources of titanium dioxide to observe the long-term effects of low dose intake on health. They found that long-term feeding mice containing 0.1% titanium dioxide nano particles of food, the macrophage chemotaxis and phagocytosis were decreased and tended to proinflammatory state, in vitro experiments further confirmed this effect. In the sepsis model, mice fed titanium dioxide nanoparticles reacted more acutely, resulting in greater damage to the body. In the TLR4 knock out and non TLR4 dependent models, TiO2 nanoparticles do not produce significant adverse effects.
The experimental results show that TiO2 nanoparticles induce abnormal activation of macrophages in TLR4 dependent manner, which may have adverse health effects on the body under conditions such as infection and other stimuli.